Direct α‐Functionalization of Saturated Cyclic Amines

Direct α‐Functionalization of Saturated Cyclic Amines

Source :

• Chemistry – A European Journal [ 0947-6539 ] ; 2012-08-13.

Descripteurs français

• Wicri :
  • topic : Méthanol, Protocole.

English descriptors

• KwdEn :
  • Activation step, Active ligand, Additive, Alkaloid, Allyl, Allyl bromide, Allylation, Amination, Amine, Analogue, Angew, Anion, Anodic, Anodic oxidation, Antwerp, Aryl, Aryl bromides, Arylation, Arylboronate ester, Asymmetric, Asymmetric deprotonation, Asymmetric synthesis, Axial position, Basl, Beng, Benzylic, Better understanding, Bispidine, Bromide, Bu3sncl, Campos, Carbanion, Carbophilic iprauotf, Catalysis, Catalyst, Catalytic, Catalytic cycle, Cation, Cation pool, Cf3cooh, Chair conformation, Chem, Chemical oxidant, Chiral, Chiral ligand, Chiral ligands, Closure, Co2me, Coldham, Commun, Cooling cycle, Cyanation, Cyanide, Cyclic, Cyclic amines, Cyclic amines review scheme, Cyclic amines scheme, Deprotonation, Derivative, Dialkyl, Dialkyl malonates, Dialkyl phosphonates, Diamine, Diastereomeric, Diastereomeric complexes, Diastereomers, Diastereoselective, Diastereoselective deprotonation, Diastereoselectivity, Direct cyanation, Direct functionalization, Dynamic resolution, Electrochemical oxidation, Electrophile, Electrophiles, Electrophilic, Electrophilic species, Enantioenriched, Enantiomer, Enantiomeric, Enantiomeric ratio, Enantiomeric ratios, Enantiomerization, Enantioselective, Enantioselective synthesis, Enantioselectivity, Equatorial, Equatorial position, Equiv, Equiv cf3cooh, Ester, Ether, External oxidant, Eyring plots, Functionality, Functionalization, Functionalized, Gawley, Gmbh, Good enantioselectivity, Good yields, Green chem, Heteroaryl bromides, Heterocyclic chemistry, High yields, Hydride shift, Iminium, Iminium ions, Iminium salt, Indole, Insertion, Intramolecular, Intramolecular amination, Inversion, Iprli, Kainic acid, Ketone, Kgaa, Leonori, Lett, Lewis acid, Lewis acid catalyst, Ligand, Lithiated, Lithiated species, Lithiation, Lithium, Lithium transmetallation, Maes, Major enantiomer, Major product, Malonates, Mannich, Mechanistic, Methanol, Methodology, Methyl, Methyl alkyl ketones, Methyl group, Moderate yields, Moiety, Molecular oxygen, Molecular sieves, Mono, More reactive, Morpholine, Natural products, Nbuli, Negishi, Nitroalkanes, Nitromethane, Nucleophile, Nucleophiles, Nucleophilic, Nucleophilic species, Optimized, Optimized conditions, Organolithium, Organolithium complexes, Oxidant, Oxidative, Oxidative addition, Oxidative mannich reaction, Oxidative reaction, Pathway, Ph2co, Phenyl, Phenyl group, Phenyl ring, Phnco, Photocatalyst, Pinacol ester, Piperazine, Piperidine, Piperidine derivatives, Piperidines, Poor results, Pretreated, Product formation, Product ratio, Protocol, Pyrroles, Pyrrolidine, Pyrrolidine derivatives, Pyrrolidine systems, Pyrrolidines, Quenching, Racemic, Radical intermediates, Rate constants, Reaction conditions, Reaction mechanism, Reaction mixture, Reaction time, Reactive, Reactivity series, Reagent, Review scheme, Ring closure, Ring size, Room temperature, Sbuli, Scheme, Scheme scheme, Selectivity, Sime3, Sparteine, Stereoselectivity, Steric, Steric bulk, Stoichiometric, Stoichiometric quantities, Stoichiometric quantity, Substituent, Sulfamoyloxymethyl substituent, Tbhp, Tertiary, Tertiary amines, Tertiary cyclic amines, Tetrahedron, Tetrahedron lett, Tetrahydroisoquinoline, Tetrahydroisoquinolines, Thermal oxidation, Thermodynamic, Thermodynamic data, Thermodynamic parameters, Thermodynamic resolution, Tmeda, Tmscl, Tour mechanism, Trans, Transition metals, Transmetallation, Verlag, Verlag gmbh, Weinheim, Weinheim chem, Wide variety, Zhang, Zhou, Zncl2.
• Teeft :
  • Activation step, Active ligand, Additive, Alkaloid, Allyl, Allyl bromide, Allylation, Amination, Amine, Analogue, Angew, Anion, Anodic, Anodic oxidation, Antwerp, Aryl, Aryl bromides, Arylation, Arylboronate ester, Asymmetric, Asymmetric deprotonation, Asymmetric synthesis, Axial position, Basl, Beng, Benzylic, Better understanding, Bispidine, Bromide, Bu3sncl, Campos, Carbanion, Carbophilic iprauotf, Catalysis, Catalyst, Catalytic, Catalytic cycle, Cation, Cation pool, Cf3cooh, Chair conformation, Chem, Chemical oxidant, Chiral, Chiral ligand, Chiral ligands, Closure, Co2me, Coldham, Commun, Cooling cycle, Cyanation, Cyanide, Cyclic, Cyclic amines, Cyclic amines review scheme, Cyclic amines scheme, Deprotonation, Derivative, Dialkyl, Dialkyl malonates, Dialkyl phosphonates, Diamine, Diastereomeric, Diastereomeric complexes, Diastereomers, Diastereoselective, Diastereoselective deprotonation, Diastereoselectivity, Direct cyanation, Direct functionalization, Dynamic resolution, Electrochemical oxidation, Electrophile, Electrophiles, Electrophilic, Electrophilic species, Enantioenriched, Enantiomer, Enantiomeric, Enantiomeric ratio, Enantiomeric ratios, Enantiomerization, Enantioselective, Enantioselective synthesis, Enantioselectivity, Equatorial, Equatorial position, Equiv, Equiv cf3cooh, Ester, Ether, External oxidant, Eyring plots, Functionality, Functionalization, Functionalized, Gawley, Gmbh, Good enantioselectivity, Good yields, Green chem, Heteroaryl bromides, Heterocyclic chemistry, High yields, Hydride shift, Iminium, Iminium ions, Iminium salt, Indole, Insertion, Intramolecular, Intramolecular amination, Inversion, Iprli, Kainic acid, Ketone, Kgaa, Leonori, Lett, Lewis acid, Lewis acid catalyst, Ligand, Lithiated, Lithiated species, Lithiation, Lithium, Lithium transmetallation, Maes, Major enantiomer, Major product, Malonates, Mannich, Mechanistic, Methanol, Methodology, Methyl, Methyl alkyl ketones, Methyl group, Moderate yields, Moiety, Molecular oxygen, Molecular sieves, Mono, More reactive, Morpholine, Natural products, Nbuli, Negishi, Nitroalkanes, Nitromethane, Nucleophile, Nucleophiles, Nucleophilic, Nucleophilic species, Optimized, Optimized conditions, Organolithium, Organolithium complexes, Oxidant, Oxidative, Oxidative addition, Oxidative mannich reaction, Oxidative reaction, Pathway, Ph2co, Phenyl, Phenyl group, Phenyl ring, Phnco, Photocatalyst, Pinacol ester, Piperazine, Piperidine, Piperidine derivatives, Piperidines, Poor results, Pretreated, Product formation, Product ratio, Protocol, Pyrroles, Pyrrolidine, Pyrrolidine derivatives, Pyrrolidine systems, Pyrrolidines, Quenching, Racemic, Radical intermediates, Rate constants, Reaction conditions, Reaction mechanism, Reaction mixture, Reaction time, Reactive, Reactivity series, Reagent, Review scheme, Ring closure, Ring size, Room temperature, Sbuli, Scheme, Scheme scheme, Selectivity, Sime3, Sparteine, Stereoselectivity, Steric, Steric bulk, Stoichiometric, Stoichiometric quantities, Stoichiometric quantity, Substituent, Sulfamoyloxymethyl substituent, Tbhp, Tertiary, Tertiary amines, Tertiary cyclic amines, Tetrahedron, Tetrahedron lett, Tetrahydroisoquinoline, Tetrahydroisoquinolines, Thermal oxidation, Thermodynamic, Thermodynamic data, Thermodynamic parameters, Thermodynamic resolution, Tmeda, Tmscl, Tour mechanism, Trans, Transition metals, Transmetallation, Verlag, Verlag gmbh, Weinheim, Weinheim chem, Wide variety, Zhang, Zhou, Zncl2.

Abstract

• https://api.istex.fr/document/D822348DEEE3894D374A978B9BB7FF635733E21A/fulltext/pdf

Affiliations:

• Belgique

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